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研究業績（論文：英文）

2026

Ichihara T, Hayashi Y, Sato T, Iguchi M, Toi M, Sataki H, Murakami I：

Hypoxia‑mediated Krebs von den Lungen‑6 expression in breast cancer: Implications for tumor invasion and metastasis.

Oncol Reports

Hayashi Y, Yamamoto Y, Murakami I：

Loss of Fbxw7 Disrupts Lipid Homeostasis and Autophagy in Hepatocellular Carcinoma Cells.

Medical Molecular Morphology

2025

Okada H, Hayashi Y, Furukawa N, Bunno Y, Yamamoto M, Miyazaki R, Iguchi M, Toi M, Murakami I, Tamura M：

Fascin-1 expression is associated with EMT and recurrence in thymic carcinoma: a clinicopathologic study.

Medical Molecular Morphology

Hayashi N, Matsutomo N, Tokorodani R, Fukami M, Nishimori M, Nakatani K, Yoshioka Y, Hayashi Y, Murakami I, Yamagami T, Yamamoto T, Yamamoto T：

Pilot study of a novel resection extent determination method using bone single-photon emission computed tomography-standardized uptake value in medication-related osteonecrosis of the jaw.

Dentomaxillofac Radiol.

Nakamura R, Okada M, Takahashi A, Hayashi Y, Konishi M, Ito F, Murakami I, Saito M, Akizawa T：

A synthetic nonapeptide, JAL-TA9, inhibits neuronal cytotoxicity caused by Aβ25-35 aggregation with proteolytic activity.

Neurobiol Aging

2024

Nakamura R, Matsuda A, Higashi Y, Hayashi Y, Konishi M, Saito M, Akizawa T：

An 11-mer Synthetic Peptide Suppressing Aggregation of Aβ25-35 and Resolving Its Aggregated Form Improves Test Performance in an Aβ25-35-Induced Alzheimer's Mouse Model.

Biomolecules

2023

Hayashi Y, Yamamoto Y, Murakami I：

Micromorphological observation of HLE cells under knockdown of Fascin using LV-SEM,

Medical Molecular Morphology

Yamamoto Y, Hayashi Y, Sakaki H, Murakami I：

Downregulation of fascin induces collective cell migration in triple negative breast cancer.

Oncology Reports.

2022

Hayashi Y, Yamamoto Y, Murakami I:

Fascin expression persisted with fibronectin in embryonic rat hepatoblasts.

Med Mol Morphol.

Yamamoto Y, Hayashi Y, Sakaki H, Murakami I：

Evaluation of Clinical and Immunohistochemical Factors Relating to Melanoma Metastasis: Potential Roles of Nestin and Fascin in Melanoma.

Diagnostics (Basel).

2021

Yamamoto Y, Hayashi Y, Sakaki Hideyuki, Murakami I：

Fascin-1 is associated with recurrence in solitary fibrous tumor /hemangiopericytoma.

Mol Clin Oncol.

2020

Yamamoto Y, Hayashi Y, Murakami I：

Recurrence of Solitary Fibrous Tumor/Hemangiopericytoma Could Be Predicted by Ki-67 Regardless of Its Origin.

Acta Med. Okayama.

2019

Yorita K, Togashi Y, Nakagawa H, Miyazaki K, Sakata S, Baba S, Takeuchi K, Hayashi Y, Murakami I, Kuroda N, Oda Y, Kohashi K, Yamada Y, Kiyozawa D, Michael Michal：

Vocal Cord Inflammatory Myofibroblastic Tumor With Mucoid Deposits Harboring TIMP3-ALK Fusion: A Potential Diagnostic Pitfall.

Pathol Int.

2018

Toi M, Hayashi Y, Murakami I：

Hepatic stellate cells derived from the nestin-positive cells in septum transversum during rat liver development.

Med Mol Morphol.

2017

Machihara K, Tanaka H, Hayashi Y, Murakami I, Namba T：

Questiomycin A stimulates sorafenib-induced cell death via suppression of glucose-regulated protein 78.

Biochem Biophys Res Commun.

2016

Kuroda N, Yorita K, Naroda T, Hayashi Y, Murakami I：

Renal oncocytoma, small cell variant, with pseudorosettes, showing cyclin D1 expression and tubulovesicular cristae of mitochondria.

Pathol Int.

Toda K, Hayashi Y, Ono M, Saibara T：

Characterization of Ovarian Responses to Equine Chorionic Gonadotropin of Aromatase-Deficient Mice With or Without 17β-Estradiol Supplementation.

Endocrinology.

2015

Ochi T, Munekage K, Ono M, Higuchi T, Tsuda M, Hayashi Y, Okamoto N, Toda K, Sakamoto S, Oben JA, Saibara T:

PNPLA3 is involved in hepatic fatty acid and triglyceride metabolism through XBP1 and modulation of endoplasmic reticulum stress in mice.

Hepatol Res.46(6): 584-92.

Hayashi Y, Osanai M, Lee GH:

NOTCH2 signaling confers immature morphology and aggressiveness in human hepatocellular carcinoma cells.

Oncol Rep 34(4):1650-8.

Toda K, Hayashi Y, Ono M, Saibara T:

Co-administration of insulin with a gonadotropin partly improves ovulatory responses of estrogen-deficient mice.

Mol Cell Endocrinol. 411:177-86.

2014

Toda K, Hayashi Y, Yamashita A, Okabe M, Ono M, Saibara T:

Aromatase-null mice expressing enhanced green fluorescent protein in germ cells provide a model system to assess estrogen-dependent ovulatory responses.

Transgenic Res. 23(2):293-302.

Iguchi M, Osanai M, Hayashi Y, Koentgen F, Lee GH:

The error-prone DNA polymerase ι provides quantitative resistance to lung tumorigenesis and mutagenesis in mice.

Oncogene. 33(27):3612-7.

2012

Toda K, Hayashi Y, Ono M, Saibara T:

Impact of ovarian sex steroids on ovulation and ovulatory gene induction in aromatase-null mice.

Endocrinology. 153(1):386-94.

Watanabe K, Hamada F, Wakatsuki A, Nagai R, Shinohara K, Hayashi Y, Imamura R, Fukaya T:

Prophylactic administration of melatonin to the mother throughout pregnancy can protect against oxidative cerebral damage in neonatal rats.

J Matern Fetal Neonatal Med. 25(8):1254-9.

2011

Kuroda N, Tamura M, Hes O, Michal M, Shuin T, Toi M, Hayashi Y, Lee GH:

Chromophobe renal cell carcinoma with prominent lymph node metastasis and polysomy of chromosome 21: poorly differentiated form or "presarcomatoid" form?

Med Mol Morphol. 44(3):168-73.

Hayashi Y, Osanai M, Lee GH:

Fascin-1 expression correlates with repression of E-cadherin expression in hepatocellular carcinoma cells and augments their invasiveness in combination with matrix metalloproteinases.

Cancer Sci. 102(6):1228-35.

2010

Asanuma T, Ono M, Kubota K, Hirose A, Hayashi Y, Saibara T, Inanami O, Ogawa Y, Enzan H, Onishi S, Kuwabara M, Oben JA:

Super paramagnetic iron oxide MRI shows defective Kupffer cell uptake function in non-alcoholic fatty liver disease.

Gut 59(2):258-66.

Hamada F, Watanabe K, Wakatsuki A, Nagai R, Shinohara K, Hayashi Y, Imamura R, Fukaya T:

Therapeutic effects of maternal melatonin administration on ischemia/reperfusion-induced oxidative cerebral damage in neonatal rats.

Neonatology 98(1):33-40.

Kuroda N, Kazakov DV, Hes O, Michal M, Goda M, Miyazaki K, Hayashi Y, Okamoto S, Lee GH:

Hybrid peripheral nerve sheath tumor of the nasal cavity showing schwannomatous, neurofibromatous, and perineuriomatous areas.

Med Mol Morphol. 43(2):82-5.

Fujieda M, Morita T, Naruse K, Hayashi Y, Ishihara M, Yokoyama T, Toma T, Ohta K, Wakiguchi H:

Effect of pravastatin on cisplatin-induced nephrotoxicity in rats.

Hum Exp Toxicol. 30(7):603-15.

Toda K, Hayashi Y, Saibara T:

Deletion of tumor necrosis factor-alpha receptor type 1 exacerbates insulin resistance and hepatic steatosis in aromatase knockout mice.

Biochim Biophys Acta. 1801(6):655-64.

Ohtsuki Y, Fukumoto T, Okada Y, Teratani Y, Hayashi Y, Lee GH, Furihata M:

Immunohistochemical and ultrastructural characterization of the signet-ring cell carcinoma component in a case of urothelial carcinoma of the urinary bladder.

Med Mol Morphol. 43(2):96-101.

2009

Kuroda N, Hamaguchi N, Inoue K, Ohara M, Mizuno K, Hayashi Y, Lee GH:

Application of immunocytochemistry to the diagnosis of primary epithelioid angiosarcoma of the lung.

Med Mol Morphol. 42(4):250-3.

Kuroda N, Sogoh T, Ohara M, Hirouchi T, Mizuno K, Hayashi Y, Lee GH:

Clear cell chondrosarcoma: an ultrastructural study.

Med Mol Morphol. 42(3):185-8.

Yamasaki K, Hayashi Y, Okamoto S, Osanai M, Lee GH:

Insulin-independent promotion of chemically induced hepatocellular tumor development in genetically diabetic mice.

Cancer Sci. 101(1):65-72.

Ohtsuki Y, Watanabe R, Kimura M, Okamoto T, Murakami S, Mizukami Y, Takeji M, Okada Y, Hayashi Y, Lee GH, Furihata M:

Immunohistochemical and electron microscopic studies of a case of duodenal gangliocytic paraganglioma.

Med Mol Morphol. 42(4):245-9.

Nagatsuma K, Hayashi Y, Hano H, Sagara H, Murakami K, Saito M, Masaki T, Lu T, Tanaka M, Enzan H, Aizawa Y, Tajiri H, Matsuura T:

Lecithin: retinol acyltransferase protein is distributed in both hepatic stellate cells and endothelial cells of normal rodent and human liver.

Liver Int 29(1):47-54.

2008

Kuroda N, Tamura M, Taguchi T, Tominaga A, Hes O, Michal M, Ohara M, Hirouchi T, Mizuno K, Hayashi Y, Shuin T, Lee GH:

Sarcomatoid acquired cystic disease-associated renal cell carcinoma.

Histol Histopathol 23(11):1327-31.

Kuroda N, Tamura M, Ohara M, Hirouchi T, Mizuno K, Miyazaki E, Hayashi Y, Lee GH:

Possible identification of third stromal component in extraadrenal paraganglioma: myofibroblast in fibrous band and capsule.

Med Mol Morphol 41(1):59-61.

Kuroda N, Tanida N, Oonishi K, Inoue K, Ohara M, Mizuno K, Taguchi T, Hayashi Y, Hanazaki K, Lee GH:

Significance of D2-40 expression in the diagnosis of gastrointestinal stromal tumor.

Med Mol Morphol 41(2):109-12.

Nagai R, Watanabe K, Wakatsuki A, Hamada F, Shinohara K, Hayashi Y, Imamura R, Fukaya T:

Melatonin preserves fetal growth in rats by protecting against ischemia/reperfusion-induced oxidative/nitrosative mitochondrial damage in the placenta.

J Pineal Res 45(3):271-6.

Radhakrishnan G, Suzuki R, Maeda H, Yamamoto M, Hirose N, Gopalrao RK, Lee GH, Hayashi Y, Rao P, Sasaguri S:

Inhibition of neointimal hyperplasia development by MCI-186 is correlated with downregulation of nuclear factor-kappaB pathway.

Circ J 72(5):800-6.

Hayashi Y, Toda K, Saibara T, Okamoto S, Osanai M, Enzan H, Lee GH：

Expression of fascin-1, an actin-bundling protein, in migrating hepatoblasts during rat liver development.

Cell Tissue Res. 334(2):219-26.

Hirose N, Maeda H, Yamamoto M, Hayashi Y, Lee GH, Chen L, Radhakrishnan G, Rao P, Sasaguri S:

The local injection of peritoneal macrophages induces neovascularization in rat ischemic hind limb muscles.

Cell Transplant 17(1-2):211-22.

Kuroda N, Fujishima N, Inoue K, Ohara M, Hirouchi T, Mizuno K, Hayashi Y, Lee GH:

Basal-like carcinoma of the breast: further evidence of the possibility that most metaplastic carcinomas may be actually basal-like carcinomas.

Med Mol Morphol 41(2):117-20.

Kuroda N, Hamaguchi N, Ohara M, Hirouchi T, Mizuno K, Hayashi Y, Lee GH:

Elastofibroma: a histochemical, immunohistochemical, and ultrastructural study of two patients.

Med Mol Morphol. 41(3):179-82.

Kuroda N, Hes O, Michal M, Nemcova J, Gal V, Yamaguchi T, Kawada T, Imamura Y, Hayashi Y, Lee GH:

Mucinous tubular and spindle cell carcinoma with Fuhrman nuclear grade 3: a histological, immunohistochemical, ultrastructural and FISH study.

Histol Histopathol 23(12):1517-23.

Matsumoto M, Hayashi Y, Ohtsuki Y, Ikegami N, Toi M, Iguchi M, Hiroi M:

Signet-ring stromal tumor of the ovary: an immunohistochemical and ultrastructural study with a review of the literature.

Med Mol Morphol. 41(3):165-70.

Toda K, Okada T, Hayashi Y, Saibara T:

Preserved tissue structure of efferent ductules in aromatase-deficient mice.

J Endocrinol 199(1):137-46.

Kuroda N, Fujishima N, Ohara M, Hirouchi T, Mizuno K, Hayashi Y, Lee GH：

Coexistent adenomyoepithelioma and invasive ductal carcinoma of the breast: presentation as separate tumors.

Med Mol Morphol. 41(4):238-42.

2007

Kuroda N, Inoue Y, Taguchi T, Tominaga A, Hes O, Michal M, Hayashi Y, Hiroi M, Shuin T, Lee GH:

Renal leiomyoma: an immunohistochemical, ultrastructural and comparative genomic hybridization study.

Histol Histopathol 22(8):883-8.

Kuroda N, Inui Y, Ohara M, Hirouchi T, Mizuno K, Kubo A, Hayashi Y, Enzan H, Lee GH:

Hyaline globule-like structures in undifferentiated sarcoma cells of malignant mllerian mixed tumor of the fallopian tube.

Med Mol Morphol. 40(1):46-9

Kuroda N, Oonishi K, Ohara M, Hirouchi T, Mizuno K, Hayashi Y, Lee GH:

Invasive micropapillary carcinoma of the colon: an immunohistochemical study.

Med Mol Morphol 40(4):226-30.

Kuroda N, Iwamura S, Fujishima N, Ohara M, Hirouchi T, Mizuno K, Hayashi Y, Lee GH:

Anaplastic carcinoma of the pancreas with rhabdoid features and hyaline globule-like structures.

Med Mol Morphol 40(3):168-71.

Kuroda N, Katto K, Tamura M, Shiotsu T, Hes O, Michal M, Nagashima Y, Ohara M, Hirouchi T, Mizuno K, Hayashi Y, Lee GH:

Carcinoid tumor of the renal pelvis: consideration on the histogenesis.

Pathol Int 58(1):51-4.

Shimasaki N, Kuroda N, Miyazaki E, Hayashi Y, Toi M, Hiroi M, Enzan H, Shuin T:

Distribution and role of myofibroblasts in human normal seminal vesicle stroma.

Med Mol Morphol 40(4):208-11.

Yamamoto M, Maeda H, Hirose N, Radhakrishnan G, Katare RG, Hayashi Y, Rao P, Lee GH, Yamaguchi T, Sasaguri S:

Bilirubin oxidation provoked by nitric oxide radicals predicts the progression of acute cardiac allograft rejection.

Am J Transplant 7(8):1897-906.

2006

Enzan H, Toi M, Hayashi Y,Hamauzu T, Kuroda N, Hiroi M :

Zone 3 Predominance of Histopathological Features in Nonalcoholic Steatohepatitis.

NASH and Nutritional Therapy:55-57

Fujieda M, Naruse K, Hamauzu T, Miyazaki E, Hayashi Y, Enomoto R, Lee E, Ohta K, Wakiguchi H, Enzan H:

Effect of selenium on Cisplatin-induced nephrotoxicity in rats.

Nephron Exp Nephrol. 104(3):e112-22.

Jin YL, Enzan H, Kuroda N, Hayashi Y, Toi M, Miyazaki E, Hamauzu T, Hiroi M, Guo LM, Shen ZS, Saibara T:

Vascularization in tissue remodeling after rat hepatic necrosis induced by dimethylnitrosamine.

Med Mol Morphol 39(1):33-43.

Hamauzu T, Kuroda N, Guo L, Miyazaki E, Hayashi Y, Toi M, Hiroi M, Enzan H:

CAM5.2-positive subserosal myofibroblasts in appendicitis.

Med Mol Morphol 39(4):209-13.

Fujieda M, Naruse K, Hamauzu T, Miyazaki E, Hayashi Y, Enomoto R, Lee E, Ohta K, Yamaguchi Y, Wakiguchi H, Enzan H:

Effect of selenium-deficient diet on tubular epithelium in normal rats.

Pediatr Nephrol 22(2):192-201.

Guo L, Enzan H, Hayashi Y, Miyazaki E, Jin Y, Toi M, Kuroda N, Hiroi M:

Increased iron deposition in rat liver fibrosis induced by a high-dose injection of dimethylnitrosamine.

Exp Mol Pathol 81(3):255-61.

Guo L, Kuroda N, Nakayama H, Miyazaki E, Hayashi Y, Toi M, Hiroi M, Enzan H:

Cytokeratin-positive subserosal myofibroblasts in gastroduodenal ulcer; another type of myofibroblasts.

Histol Histopathol 21(7):697-704.

Kuroda N, Takahashi T, Moriki T, Okanoue Y, Mizobuchi H, Miyazaki E, Hayashi Y, Lee GH:

A skin tumor with metastasis to the scalp: a histochemical, immunohistochemical and ultrastructural study.

Med Mol Morphol. 39(4):221-5.

Shimasaki N, Kuroda N, Miyazaki E, Hayashi Y, Toi M, Hiroi M, Enzan H, Shuin T:

The distribution pattern of myofibroblasts in the stroma of human bladder carcinoma depends on their invasiveness.

Histol Histopathol 21(4):349-53.

2005

Zhang Y, Hayashi Y, Cheng X, Watanabe T, Wang X, Taniguchi N, Honke K:

Testis-specific sulfoglycolipid, seminolipid, is essential for germ cell function in spermatogenesis.

Glycobiology. 15(6):649-54.

Shimasaki N, Kuroda N, Guo L, Jin Y, Miyazaki E, Hayashi Y, Toi M, Hiroi M, Enzan H, Shuin T:

The participation of myofibroblasts in the capsular formation of human conventional and chromophobe renal cell carcinomas.

Histol Histopathol 20(1):67-73.

Toda K, Hayashi Y, Okada T, Morohashi K, Saibara T:

Expression of the estrogen-inducible EGFP gene in aromatase-null mice reveals differential tissue responses to estrogenic compounds.

Mol Cell Endocrinol 14;229(1-2):119-26.

Hayashi Y, Toda K, Saibara T, Okada T, Enzan H:

Assessment of anti-estrogenic activity of tamoxifen in transgenic mice expressing an enhanced green fluorescent protein gene regulated by estrogen response element.

Biochim Biophys Acta 1760(2):164-71.

2004

Nozaki Y, Saibara T, Nemoto Y, Ono M, Akisawa N, Iwasaki S, Hayashi Y, Hiroi M, Enzan H, Onishi S:

Polymorphisms of interleukin-1 beta and beta 3-adrenergic receptor in Japanese patients with nonalcoholic steatohepatitis.

Alcohol Clin Exp Res 28:106S-110S

Kuroda N, Ishiura Y, Kawashima M, Miyazaki E, Hayashi Y, Enzan H:

Distribution of myofibroblastic cells in the liver and kidney of Meckel-Gruber syndrome.

Pathol Int. 54: 57-62

Kuroda N, Nakayama H, Miyazaki E, Hayashi Y, Toi M, Hiroi M, Enzan H:

The distribution and role of myofibroblasts and CD34-positive stromal cells in normal pancreas and various pancreatic lesions.

Histol Histopathol.19:59-67

Kuroda N, Satake H, Miyazaki E, Hayashi Y, Hiroi M, Enzan H:

Collecting duct carcinoma exhibiting diastase-resistant PAS-positive globular cytoplasmic inclusions and rhabdoid features arising in adult polycystic kidney disease: a case report.

Int J Surg Pathol 12(2):171-7.

Kuroda N, Toi M, Nakayama H, Miyazaki E, Yamamoto M, Hayashi Y, Hiroi M, Enzan H:

Immunohistochemical identification of intracytoplasmic Lumens by cytokeratin typing may differentiate renal oncocytomas from chromophobe renal cell carcinomas.

Histol Histopathol. 19:23-28,

Ozaki A, Fukushima A, Ishida W, Zinchuk O, Fukata K, Hayashi Y, Enzan H, Takata M, Yagita H, Ueno H:

Analysis of Ag-presenting cells in the conjunctiva during the development of experimental immune-mediated blepharoconjunctivitis.

Curr Eye Res 29(4-5):277-86.

Kuroda N, Nakayama H, Miyazaki E, Hayashi Y, Toi M, Hiroi M and Enzan H:

Distribution and role of CD34-positive stromal cells and myofibroblasts in human normal testicular stroma.

Histol Histopathol 19:743-751.

Kuroda N, Senzaki T, Yamasaki Y, Miyazaki E, Hayashi Y, Toi M, Hiroi M, Enzan H:

Sertoli cell tumor of the testis (not otherwise specified) with the expression of neuroendocrine markers and without the expression of inhibin-alpha.

Pathol Int 54(9):719-24.

Kuroda N, Nakamura S, Miyazaki E, Hayashi Y, Taguchi T, Hiroi M, Yamasaki Y, Shuin T, Enzan H:

Low-grade tubular-mucinous renal neoplasm with neuroendocrine differentiation: a histological, immunohistochemical and ultrastructural study.

Pathol Int 54(3):201-7.

Nozaki Y, Saibara T, Nemoto Y, Ono M, Akisawa N, Iwasaki S, Hayashi Y, Hiroi M, Enzan H, Onishi S:

Polymorphisms of interleukin-1 beta and beta 3-adrenergic receptor in Japanese patients with nonalcoholic steatohepatitis.

Alcohol Clin Exp Res 28(8 Suppl Proceedings):106S-110S.

Kuroda N, Ishiura Y, Kawashima M, Miyazaki E, Hayashi Y, Enzan H:

Case report. Distribution of myofibroblastic cells in the liver and kidney of Meckel Gruber syndrome.

Pathol Int. 54. 57-62.

Kuroda N, Miyazaki E, Hayashi Y, Toi M, Hiroi M and Enzan H:

The disappearance of CD34-positive and alpha-smooth muscle actin-positive stromal cells associated with human intra-uterine and tubal pregnancies.

Histol Histopathol 19:707-713.

2003

Egawa T, Toda K, Nemoto Y, Ono M, Akisaw N, Saibara T, Hayashi Y, Hiroi M, Enzan H, Onishi S:

Pitavastatin ameliorates severe hepatic steatosis in aromatase-deficient (Ar-/-) mice.

Lipids 38(5):519-23.

Hiroi M, Kuroda N, Toi M, Hayashi Y, Miyazaki E, Naruse K, Enzan H:

Fascin-positive dendritic cells and fibroblastic reticulum cells build a framework of T-cell areas in lymph nodes.

Virchows Arch 444(2):158-63.

Jin Y, Enzan H, Kuroda N, Hayashi Y, Nakayama H, Zhang Y, Toi M, Miyazaki E, Hiroi M, Guo L, Saibara T:

Tissue remodeling following submassive hemorrhagic necrosis in rat livers induced by an intraperitoneal injection of dimethylnitrosamine.

Virchows Arch. 442:39-47,

Kawai S, Enzan H, Hayashi Y, Jin YL, Guo LM, Miyazaki E, Toi M, Kuroda N, Hiroi M, Saibara T, Nakayama H:

Vinculin: a novel marker for quiescent and activated hepatic stellate cells in human and rat livers.

Virchows Arch 443(1):78-86.

2002

Yoshikawa T, Toda K, Nemoto Y, Ono M, Iwasaki S, Maeda T, Saibara T, Hayashi Y, Iwasaki S, Miyazaki E, Hiroi M, Enzan H, Shizuta Y:

Aromatase-deficient (ArKO) mice are retrieved from sever hepatic steatosis by peroxisome proliferator administration.

Hepatol Res: 278-287.

Kuroda N, Toi M, Miyazaki E, Hayashi Y, Nakayama H, Hiroi M and Enzan H:

Participation of α-smooth muscle actin-positive cells in renomedullary interstitial cell tumors.

Oncol Rep 9:745-750.

Li C, Toda K, Saibara T, Zhang T, Ono M, Iwasaki S, Maeda T, Okada T, Hayashi Y, Enzan H, Shizuta Y, Onishi S:

Estrogen deficiency results in enhanced expression of Smoothened of the Hedgehog signaling in the thymus and affects thymocyte development.

Int Immunopharmacol 2:823-833.

2001

Kuroda N, Sugimoto T, Ueda S, Takahashi T, Moriki T, Sonobe H, Miyazaki E, Hayashi Y, Toi M, Hiroi M, Enzan H:

Malignant phyllodes tumor of the breast with expression of osteonectin and vinculin.

Pathol Int. 51(4):277-82.

Guo L, Kuroda N, Toi M, Miyazaki E, Hayashi Y, Enzan H, Jin Y:

Increased expression of platelet-derived endothelial cell growth factor in human hepatocellular carcinomas correlated with high Edmondson grades and portal vein tumor thrombosis.

Oncol Rep 8(4):871-6.

Guo L, Kuroda N, Miyazaki E, Hayashi Y, Toi M, Naruse K, Hiroi M, Ashida S, Shuin T, Enzan H:

The complementary role of beta-catenin in diagnosing various subtypes of renal cell carcinomas and its up-regulation in conventional renal cell carcinomas with high nuclear grades.

Oncol Rep 8(3):521-6.

Saibara T, Ono M, Iwasaki S, Maeda T, Onishi S, Hayashi Y, Enzan H:

Effects of ethanol on L-arginine transport in rat Ito cell in relation to nitric oxide production.

Alcoholism: Clin and Exptl Res 25(6):39S-45S.

Toi M, Kuroda N, Tao L, Jin Y, Guo L, Miyazaki E, Hayashi Y, Hiroi M, Komatsu N, Nakata H, Ogata K, Enzan H:

Adult-onset herpes simplex virus hepatitis with diffuse myofibroblastic transformation of hepatic stellate cells (Ito cells) in non-necrotic areas.

Pathol Int 51(4):288-92.

Kuroda N, Guo L, Toi M, Naruse K, Miyazaki E, Hayashi Y, Yoshikawa C, Ashida S, Shuin T, Enzan H:

Paxillin: application of immunohistochemistry to the diagnosis of chromophobe renal cell carcinoma and oncocytoma.

Appl Immunohistochem Mol Morphol 9(4):315-8.

Kuroda N, Sugimoto T, Ueda S, Takahashi T, Moriki T, Sonobe H, Miyazaki E, Hayashi Y, Toi M, Hiroi M, Enzan H:

Case Report. Malignant phyllodes tumor of the breast with expression of osteonectin and vinculin.

Pathol Int 51:277-282.

Kuroda N, Inoue E, Guo L, Miyazaki E, Hayashi Y, Naruse K, Toi M, Hiroi M, Shuin T, Enzan H:

Expression of CD9/Motility-Related Protein 1 (MRP-1) in papillary and chromophobe renal cell carcinomas.

Human Pathol 32(10), 1071-1077.

2000

Hiroi M, Fukunaga T, Miyazaki E, Hayashi Y, Kuroda N, Toi M, Naruse K, Nakayama H, Kiyoku H, Enzan H:

Adenoid basal carcinoma of the uterine cervix: a case report with ultrastructural findings.

Med Electron Microsc. 33(4):241-5.

Naruse K, Fujieda M, Miyazaki E, Hayashi Y, Toi M, Fukui T, Kuroda N, Hiroi M, Kurashige T, Enzan H:

An immunohistochemical study of developing glomeruli in human fetal kidneys.

Kidney Int. 357(5):1836-46.

Tao L, Enzan H, Hayashi Y, Miyazaki E, Saibara T, Hiroi M, Toi M, Kuroda N, Naruse K, Jin Y, Guo L:

Appearance of denuded hepatic stellate cells and their subsequent myofibroblast-like transformation during the early stage of biliary fibrosis in the rat.

Med Electron Microsc 33 (4):217-230.

Jin Y, Kuroda N, Kakiuchi S, Yamasaki Y, Miyazaki E, Hayashi Y, Toi M, Naruse K, Hiroi M, and Enzan H:

Bronchial granular cell tumor with osteopontin and osteonectin expression: A case report.

Pathol Int 50(5):421-426.

Hiroi M, Fukunaga T, Miyazaki E, Hayashi Y, Kuroda N, Toi M, Naruse K, Nakayama H, Kiyoku H, Enzan H:

Haemoid basal carcinoma of the uterine cervix: a case report with ultrastructural findings.

Med Electron Microsc 33 (4), 241-245.

Kuroda N, Moriki T, Komatsu F, Miyazaki E, Hayashi Y, Naruse K, Nakayama H, Kiyoku H, Hiroi M, Shuin T, Enzan H:

Adult-onset giant juxtaglomerular cell tumor of the kidney.

Pathol Int 50(3):249-254.

Kuroda N, Naruse K, Miyazaki E, Hayashi Y, Yoshikawa C, Ashida S, Moriki T, Yamasaki Y, Numoto S, Yamamoto Y, Yamasaki I, Hiroi M, Shuin T, Enzan H:

Vinculin: its possible use as a marker of normal collecting ducts and renal neoplasms with collecting duct system phenotype.

Mod Pathol 13(10):1109-14.

Kuroda N, Sawada T, Miyazaki E, Hayashi Y, Toi M, Naruse K, Fukui T, Nakayama H, Hiroi M, Taguchi H, Enzan H:

Anaplastic carcinoma of the pancreas with rhabdoid features.

Pathol Int 50(1):57-62.

Narumoto K, Saibara T, Maeda T, Onishi S, Hayashi Y, Miyazaki E, Hiroi M, Enzan H, Kobayashi N:

Transforming growth factor-beta1 derived from biliary epithelial cells may attenuate alloantigen-specific immune responses.

Transplant Int 13(1):21-27.

Naruse K, Fujieda M, Miyazaki E, Hayashi Y, Toi M, Kuroda N, Hiroi M, Kurashige T, Enzan H:

Mesangial myofibroblastic transformation in steroid-dependent minimal change nephrotic syndrome.

Med Electron Microsc 33(2):102-7.

1999

Naruse K, Fujieda M, Miyazaki E, Hayashi Y, Kuroda N, Nakayama H, Kiyoku H, Hiroi M, Kurashige T, Enzan H:

CD34 expression as a novel marker of transformed mesangial cells in biopsied glomerular diseases.

J Pathol 189(1): 105-111.

Hiroi M, Hayashi Y, Tsuda K, Saibara T, Onishi S, Miyazaki E, Kuroda N, Nakayama H, Kiyoku H, Tao L, Enzan H:

Degranulation of mast cells and interstitial cells in portal tracts, early changes in the common bile duct ligation of rat livers.

Lymphoreticular cells and diseases 6:329-336.

Hiroi M, Tsuda K, Saibara T, Onishi S, Hayashi Y, Nakayama H, Kiyoku H, Tao LH, and Enzan H:

Mast cells and the activation of interstitial cells in rat liver fibrosis induced by ligation of common bile ducts.

Wisse E, Knook DL, de Zanger R, Fraser R, eds. Cells of the Hepatic Sinusoid Vol 7, Kupffer Cell Foundation, Leiden: 181-182.

Saibara T, Ookawauchi K, Yoshikawa T, Li CL, Tsuda K, Ono M, Iwasaki S, Maeda T, Onishi S, Miyazaki E, Hayashi Y, Hiroi M, Enzan H:

Cationic amino acid transporter in rat Ito cells.

Wisse E, Knook DL, de Zanger R, Fraser R, eds. Cells of the Hepatic Sinusoid Vol 7, Kupffer Cell Foundation, Leiden: 30-31.

Enzan H, Hayashi Y, Miyazaki E, Naruse K, Tao LH, Kuroda N, Nakayama H, Hiroi M, Kiyoku H, Saibara T:

Morphological aspects of hepatic fibrosis and Ito cells (hepatic stellate cells), with special reference to their myofibroblastic transformation.

Tanikawa K, Ueno T, eds. Liver Diseases and Hepatic Sinusoidal cells, Springer, Tokyo: 219-231.

1998

Kuroda N, Hayashi Y, Itoh H:

A case of chromophobe renal cell carcinoma with sarcomatoid foci and a small daughter lesion.

Pathol Int. 48(10):812-7.

Naruse K, Ito H, Moriki T, Miyazaki E, Hayashi Y, Nakayama H, Kiyoku H, Hiroi M, Kurashige T, Enzan H:

Mesangial cell activation in the collagenofibrotic glomerulonephropathy. Case report and review of the literature.

Virchows Arch 433(2):183-188.

Nojima Y, Enzan H, Hayashi Y, Nakayama H, Kiyoku H, Hiroi M, Mori K:

Neuroepithelial and ependymal changes in HTX rats with congenital hydrocephalus: an ultrastructural and immunohistochemical study.

Pathol Int 48(2):115-25.

Ookawauchi K, Saibara T, Yoshikawa T, Chun-Lin L, Hayashi Y, Hiroi M, Enzan H, Fukata J, Onishi S:

Characterization of cationic amino acid transporter and its gene expression in rat hepatic stellate cells in relation to nitric oxide production.

J Hepatol 29(6):923-32.

Tomoda T, Kurashige T, Hayashi Y, Enzan H:

Primary changes in liver damage by aspirin in rats.

Acta Paediatr Jpn 40(6):593-596.

1997

Hiroi M, Hayashi Y, Naruse K, Nakayama H, Kiyoku H, Enzan H, et al.:

Ultrastructural changes of rat Ito cells of the liver during its transformation in vitro.

Lymphoreticular cells and diseases, Lee J-D and Takahashi K, eds. Hematolymphoreticular Study Group, The Korean Society of Pathologists, Seoul, Korea: 123-131.

Saibara T, Enzan H, Hiroi M, Kiyoku H, Hayashi Y, Tsuda K, and Onishi S:

Ultrastructural study of Ito cells in the region of piecemeal necrosis.

Wisse E, Knook DL, and Balabaud C, eds. Cells of the Hepatic Sinusoid 6. Kupffer Cell Foundation, Leiden: 114-115.